Megasync register trial#

Predicting intracranial pressure and brain tissue oxygen crises in patients with severe traumatic brain injury. Myers R.B., Lazaridis C., Jermaine C.M., Robertson C.S., Rusin C.G. Brain anaerobic lactate production: a suicide note or a survival kit? Dev Neurosci. The protocol and planned analyses are reported here to mitigate analysis bias.Īustralian and New Zealand Clinical Trials Registry (ACTRN 12620000391976).Ĭritical care Hyperoxaemia Hypoxaemia Intensive care Oxygen Oxygen therapy Stroke Subarachnoid haemorrhage Traumatic brain injury. liberal oxygen therapy regimens on 90-day in-hospital mortality in adults in the ICU with acute brain injuries and conditions. Mega-ROX Brains will compare the effect of conservative vs.

Secondary outcomes include duration of survival, duration of mechanical ventilation, ICU length of stay, hospital length of stay, and the proportion of participants discharged home. The primary outcome is in-hospital all-cause mortality up to 90 d from the date of randomisation.

We expect to enrol between 75 participants with nonhypoxic ischaemic encephalopathy acute brain injuries and conditions who are receiving unplanned invasive mechanical ventilation in the ICU.

Megasync register trial#

Mega-ROX Brains is an international randomised clinical trial, which will be conducted within an overarching 40,000-participant, registry-embedded clinical trial comparing conservative and liberal ICU oxygen therapy regimens. The objective of this study was to summarise the protocol and statistical analysis plan for the Mega-ROX Brains trial. liberal oxygen therapy on 90-day in-hospital mortality in adults who have nonhypoxic ischaemic encephalopathy acute brain injuries and conditions and are receiving invasive mechanical ventilation in the intensive care unit (ICU) is uncertain.

29 School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

28 Brazilian Research in Intensive Care Network - BricNet, Brazil.

27 HCor Research Institute, São Paulo, Brazil.

26 Division of Surgery and Interventional Science, University College London, London, UK.

25 University College London, Institute of Health Informatics, London, UK.

24 Department of Anaesthesia and Intensive Care, St Vincent's Hospital, Dublin, Ireland.

23 School of Medicine and Medical Sciences, University College Dublin, Ireland.

22 Department of Critical Care Medicine, Fortis Escorts Hospital, Jaipur, India.

21 The George Institute for Global Health, Sydney, New South Wales, Australia.

20 The Intensive Care Unit, Alfred Health, Melbourne, Victoria, Australia.

19 University College Hospital, London, UK.

18 Nuffield Department of Medicine, University of Oxford, Oxford, UK.

17 Department of Health Promotion and Human Behavior, Kyoto University School of Public Health, Kyoto, Japan.

16 Intensive Care Unit, Jikei University Hospital, Tokyo, Japan.

15 Department of Critical Care Medicine, Sultan Qaboos Comprehensive Cancer Care and Research Center, Muscat, Oman.

14 Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.

13 National Intensive Care Surveillance - MORU (NICS-MORU), Colombo, Sri Lanka.

12 Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.

11 Department of Anaesthesiology and Intensive Care, School of Medicine, International Islamic University of Malaysia, Kuantan, Pahang, Malaysia.

10 Department of Critical Care Medicine, University of Alberta, And the Critical Care Strategic Clinical Network, Alberta Health Services, Edmonton, Alberta, Canada.

9 Department of Anesthesia and Critical Care Unit, Lady Reading Hospital, Peshawar, Pakistan.

8 College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, And Intensive Care Department, King Abdulaziz Medical City, Ministry of National-Guard Health Affairs, Riyadh, Saudi Arabia.

7 Nepal Intensive Care Research Foundation, Kathmandu, Nepal.6 Kuwait Extracorporeal Life Support Program, Al-Amiri Center for Respiratory and Cardiac Failure, Ministry of Health, Kuwait.5 Department of Anesthesia, Critical Care Medicine, and Pain Medicine, Al-Amiri Hospital, Ministry of Health, Kuwait.4 Department of Critical Care, University of Melbourne, Melbourne, Victoria, Australia.3 Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.2 Medical Research Institute of New Zealand, Wellington, New Zealand.

1 Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.